H2N2V1, Main, Exploration, bibRecord, 002B40

The role of humoral immunity in host defence against influenza A infection in mice

Identifieur interne : 002B40 ( Main/Exploration ); précédent : 002B39; suivant : 002B41

The role of humoral immunity in host defence against influenza A infection in mice

Auteurs : J. L. Virelizier ; J. S. Oxford ; G. C. Schild

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1976-06.

RBID : ISTEX:C8E5E70E56F7F6B4CDE438808B62660168526ADF

English descriptors

Teeft :
- Active immunization, Antibody, Antibody formation, Antibody response, Antibody responses, Antigenic determinants, Dead mice, Detectable antibody, Essential role, Final concentration, Haemagglutinin, Host defence, Host defences, Humoral, Humoral immunity, Immune, Immune spleen cells, Infection, Infectious diseases, Influenza, Influenza infection, Influenza virus, Influenza virus infection, Influenza viruses, Internal components, Intranasal inoculation, Lethal challenge, Lethal dose, Lethal infection, Memory cells, Mouse, Nasal secretions, National institute, Natural conditions, Organ suspensions, Previous sublethal infectiont recipients, Schild, Serum antibody, Spleen, Spleen cells, Structural antigens, Titre, Txbm, Txbm animals, Txbm mice, Virelizier, Virus, Zone area.

Abstract

The respective roles of cell-mediated immunity and humoral immunity in host defence were investigated in mice infected with influenza A/PR8 virus. Transferred immune spleen cells were shown to provide full protection only when they were actually secreting antibody. Serum antibody transferred in ‘physiological’ amounts was found to be protective in immunologically intact or in immunosuppressed animals. The specificity of the transferred antibody was shown to be critical, since antibody to internal components of the virus was inefficient while antibody to haemagglutinin, especially that to the strain-specific determinants of the haemagglutinin molecule, was highly efficient.

Url:

DOI: 10.1136/pgmj.52.608.332

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of humoral immunity in host defence against influenza A infection in mice</title>
<author><name sortKey="Virelizier, J L" sort="Virelizier, J L" uniqKey="Virelizier J" first="J. L." last="Virelizier">J. L. Virelizier</name>
</author>
<author><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J. S." last="Oxford">J. S. Oxford</name>
</author>
<author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C8E5E70E56F7F6B4CDE438808B62660168526ADF</idno>
<date when="1976" year="1976">1976</date>
<idno type="doi">10.1136/pgmj.52.608.332</idno>
<idno type="url">https://api.istex.fr/ark:/67375/NVC-X7HHLTB2-H/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000888</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000888</idno>
<idno type="wicri:Area/Istex/Curation">000888</idno>
<idno type="wicri:Area/Istex/Checkpoint">001707</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001707</idno>
<idno type="wicri:doubleKey">0032-5473:1976:Virelizier J:the:role:of</idno>
<idno type="wicri:Area/Main/Merge">002D10</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496323</idno>
<idno type="RBID">PMC:2496323</idno>
<idno type="wicri:Area/Pmc/Corpus">000434</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000434</idno>
<idno type="wicri:Area/Pmc/Curation">000434</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000434</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000E14</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E14</idno>
<idno type="wicri:Area/Ncbi/Merge">001363</idno>
<idno type="wicri:Area/Ncbi/Curation">001363</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001363</idno>
<idno type="wicri:doubleKey">0032-5473:1976:Virelizier J:the:role:of</idno>
<idno type="wicri:Area/Main/Merge">002C64</idno>
<idno type="wicri:Area/Main/Curation">002B40</idno>
<idno type="wicri:Area/Main/Exploration">002B40</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The role of humoral immunity in host defence against influenza A infection in mice</title>
<author><name sortKey="Virelizier, J L" sort="Virelizier, J L" uniqKey="Virelizier J" first="J. L." last="Virelizier">J. L. Virelizier</name>
</author>
<author><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J. S." last="Oxford">J. S. Oxford</name>
</author>
<author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Postgraduate Medical Journal</title>
<title level="j" type="abbrev">Postgrad Med J</title>
<idno type="ISSN">0032-5473</idno>
<idno type="eISSN">1469-0756</idno>
<imprint><publisher>The Fellowship of Postgraduate Medicine</publisher>
<date type="published" when="1976-06">1976-06</date>
<biblScope unit="volume">52</biblScope>
<biblScope unit="issue">608</biblScope>
<biblScope unit="page" from="332">332</biblScope>
</imprint>
<idno type="ISSN">0032-5473</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0032-5473</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active immunization</term>
<term>Antibody</term>
<term>Antibody formation</term>
<term>Antibody response</term>
<term>Antibody responses</term>
<term>Antigenic determinants</term>
<term>Dead mice</term>
<term>Detectable antibody</term>
<term>Essential role</term>
<term>Final concentration</term>
<term>Haemagglutinin</term>
<term>Host defence</term>
<term>Host defences</term>
<term>Humoral</term>
<term>Humoral immunity</term>
<term>Immune</term>
<term>Immune spleen cells</term>
<term>Infection</term>
<term>Infectious diseases</term>
<term>Influenza</term>
<term>Influenza infection</term>
<term>Influenza virus</term>
<term>Influenza virus infection</term>
<term>Influenza viruses</term>
<term>Internal components</term>
<term>Intranasal inoculation</term>
<term>Lethal challenge</term>
<term>Lethal dose</term>
<term>Lethal infection</term>
<term>Memory cells</term>
<term>Mouse</term>
<term>Nasal secretions</term>
<term>National institute</term>
<term>Natural conditions</term>
<term>Organ suspensions</term>
<term>Previous sublethal infectiont recipients</term>
<term>Schild</term>
<term>Serum antibody</term>
<term>Spleen</term>
<term>Spleen cells</term>
<term>Structural antigens</term>
<term>Titre</term>
<term>Txbm</term>
<term>Txbm animals</term>
<term>Txbm mice</term>
<term>Virelizier</term>
<term>Virus</term>
<term>Zone area</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The respective roles of cell-mediated immunity and humoral immunity in host defence were investigated in mice infected with influenza A/PR8 virus. Transferred immune spleen cells were shown to provide full protection only when they were actually secreting antibody. Serum antibody transferred in ‘physiological’ amounts was found to be protective in immunologically intact or in immunosuppressed animals. The specificity of the transferred antibody was shown to be critical, since antibody to internal components of the virus was inefficient while antibody to haemagglutinin, especially that to the strain-specific determinants of the haemagglutinin molecule, was highly efficient.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J. S." last="Oxford">J. S. Oxford</name>
<name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name>
<name sortKey="Virelizier, J L" sort="Virelizier, J L" uniqKey="Virelizier J" first="J. L." last="Virelizier">J. L. Virelizier</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B40 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B40 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:C8E5E70E56F7F6B4CDE438808B62660168526ADF
   |texte=   The role of humoral immunity in host defence against influenza A infection in mice
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

The role of humoral immunity in host defence against influenza A infection in mice

The role of humoral immunity in host defence against influenza A infection in mice

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.